Hospitalized children with influenza A H1N1 (2009) infection: a Spanish multicenter study.
Identifieur interne : 000258 ( Main/Exploration ); précédent : 000257; suivant : 000259Hospitalized children with influenza A H1N1 (2009) infection: a Spanish multicenter study.
Auteurs : Susanna Hernández-Bou [Espagne] ; Cristina Borrás Novell ; Jara Guardia Alins ; Juan José García-GarcíaSource :
- Pediatric emergency care [ 1535-1815 ] ; 2013.
Descripteurs français
- KwdFr :
- Adolescent (MeSH), Enfant (MeSH), Enfant d'âge préscolaire (MeSH), Enfant hospitalisé (MeSH), Espagne (épidémiologie), Facteurs de risque (MeSH), Femelle (MeSH), Grippe humaine (virologie), Grippe humaine (épidémiologie), Humains (MeSH), Loi du khi-deux (MeSH), Modèles logistiques (MeSH), Mâle (MeSH), Nourrisson (MeSH), Sous-type H1N1 du virus de la grippe A (MeSH).
- MESH :
- virologie : Grippe humaine.
- épidémiologie : Espagne, Grippe humaine.
- Adolescent, Enfant, Enfant d'âge préscolaire, Enfant hospitalisé, Facteurs de risque, Femelle, Humains, Loi du khi-deux, Modèles logistiques, Mâle, Nourrisson, Sous-type H1N1 du virus de la grippe A.
- Wicri :
- geographic : Espagne.
English descriptors
- KwdEn :
- Adolescent (MeSH), Chi-Square Distribution (MeSH), Child (MeSH), Child, Hospitalized (MeSH), Child, Preschool (MeSH), Female (MeSH), Humans (MeSH), Infant (MeSH), Influenza A Virus, H1N1 Subtype (MeSH), Influenza, Human (epidemiology), Influenza, Human (virology), Logistic Models (MeSH), Male (MeSH), Risk Factors (MeSH), Spain (epidemiology).
- MESH :
- geographic , epidemiology : Spain.
- epidemiology : Influenza, Human.
- virology : Influenza, Human.
- Adolescent, Chi-Square Distribution, Child, Child, Hospitalized, Child, Preschool, Female, Humans, Infant, Influenza A Virus, H1N1 Subtype, Logistic Models, Male, Risk Factors.
Abstract
OBJECTIVES
Even though the majority of cases of influenza A H1N1 (2009) in children are mild, severe complications have been reported. Our objective was to describe the Influenza A H1N1 (2009) complications in pediatric population in Spain.
METHODS
This was a multicenter descriptive study including patients younger than 14 years attending 15 emergency departments and hospitalized with laboratory-confirmed influenza A H1N1 (2009) infection from August to December 2009. Patients who did not meet any of the admission criteria recommended by the Health Spanish Authorities were excluded. A standardized report form was used to collect information on demographics, risk factors, clinical and microbiological data, treatment, and outcome. Potential risk factors associated with intensive care requirement (assisted ventilation and/or inotropic support) were analyzed.
RESULTS
Three hundred eight patients were included. The hospitalization rate was 20.5 per 100,000 children younger than 14 years. Median age was 48 months; 21% had underlying medical conditions. The most common diagnosis at admission was presumed bacterial pneumonia (42.5%). Oseltamivir was prescribed on admission to 207 children (67.2%) and antibiotics to 199 (64.6%). Bacterial coinfection was confirmed in 29 patients (9.4%). Fifty-four patients (17.5%) were admitted to an intensive care unit, and 6 (1.9%) died. Logistic regression model revealed that confirmed bacterial coinfection was associated with intensive care requirement (odds ratio, 3.3; 95% confidence interval, 1.1-10.0).
CONCLUSIONS
Respiratory manifestations were the main complication described. Although the majority of patients had a favorable evolution, a remarkable morbidity and mortality were observed. Patients with confirmed bacterial coinfection were at high risk of severe illness.
DOI: 10.1097/PEC.0b013e31827b528f
PubMed: 23283263
Affiliations:
Links toward previous steps (curation, corpus...)
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first="Jara Guardia" last="Alins">Jara Guardia Alins</name></author><author><name sortKey="Garcia Garcia, Juan Jose" sort="Garcia Garcia, Juan Jose" uniqKey="Garcia Garcia J" first="Juan José" last="García-García">Juan José García-García</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2013">2013</date><idno type="RBID">pubmed:23283263</idno><idno type="pmid">23283263</idno><idno type="doi">10.1097/PEC.0b013e31827b528f</idno><idno type="wicri:Area/Main/Corpus">00268</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">00268</idno><idno type="wicri:Area/Main/Curation">000268</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000268</idno><idno type="wicri:Area/Main/Exploration">000268</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Hospitalized children with influenza A H1N1 (2009) infection: a Spanish multicenter study.</title><author><name sortKey="Hernandez Bou, Susanna" sort="Hernandez Bou, Susanna" uniqKey="Hernandez Bou S" first="Susanna" last="Hernández-Bou">Susanna Hernández-Bou</name><affiliation wicri:level="1"><nlm:affiliation>Pediatric Emergency Department, Hospital Sant Joan de Déu Barcelona, Spain. shernandez@hsjdbcn.org</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Pediatric Emergency Department, Hospital Sant Joan de Déu Barcelona</wicri:regionArea><wicri:noRegion>Hospital Sant Joan de Déu Barcelona</wicri:noRegion></affiliation></author><author><name sortKey="Novell, Cristina Borras" sort="Novell, Cristina Borras" uniqKey="Novell C" first="Cristina Borrás" last="Novell">Cristina Borrás Novell</name></author><author><name sortKey="Alins, Jara Guardia" sort="Alins, Jara Guardia" uniqKey="Alins J" first="Jara Guardia" last="Alins">Jara Guardia Alins</name></author><author><name sortKey="Garcia Garcia, Juan Jose" sort="Garcia Garcia, Juan Jose" uniqKey="Garcia Garcia J" first="Juan José" last="García-García">Juan José García-García</name></author></analytic><series><title level="j">Pediatric emergency care</title><idno type="eISSN">1535-1815</idno><imprint><date when="2013" type="published">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent (MeSH)</term><term>Chi-Square Distribution (MeSH)</term><term>Child (MeSH)</term><term>Child, Hospitalized (MeSH)</term><term>Child, Preschool (MeSH)</term><term>Female (MeSH)</term><term>Humans (MeSH)</term><term>Infant (MeSH)</term><term>Influenza A Virus, H1N1 Subtype (MeSH)</term><term>Influenza, Human (epidemiology)</term><term>Influenza, Human (virology)</term><term>Logistic Models (MeSH)</term><term>Male (MeSH)</term><term>Risk Factors (MeSH)</term><term>Spain (epidemiology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent (MeSH)</term><term>Enfant (MeSH)</term><term>Enfant d'âge préscolaire (MeSH)</term><term>Enfant hospitalisé (MeSH)</term><term>Espagne (épidémiologie)</term><term>Facteurs de risque (MeSH)</term><term>Femelle (MeSH)</term><term>Grippe humaine (virologie)</term><term>Grippe humaine (épidémiologie)</term><term>Humains (MeSH)</term><term>Loi du khi-deux (MeSH)</term><term>Modèles logistiques (MeSH)</term><term>Mâle (MeSH)</term><term>Nourrisson (MeSH)</term><term>Sous-type H1N1 du virus de la grippe A (MeSH)</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Spain</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Grippe humaine</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Espagne</term><term>Grippe humaine</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Chi-Square Distribution</term><term>Child</term><term>Child, Hospitalized</term><term>Child, Preschool</term><term>Female</term><term>Humans</term><term>Infant</term><term>Influenza A Virus, H1N1 Subtype</term><term>Logistic Models</term><term>Male</term><term>Risk Factors</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Enfant</term><term>Enfant d'âge préscolaire</term><term>Enfant hospitalisé</term><term>Facteurs de risque</term><term>Femelle</term><term>Humains</term><term>Loi du khi-deux</term><term>Modèles logistiques</term><term>Mâle</term><term>Nourrisson</term><term>Sous-type H1N1 du virus de la grippe A</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Espagne</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>OBJECTIVES</b></p><p>Even though the majority of cases of influenza A H1N1 (2009) in children are mild, severe complications have been reported. Our objective was to describe the Influenza A H1N1 (2009) complications in pediatric population in Spain.</p></div><div type="abstract" xml:lang="en"><p><b>METHODS</b></p><p>This was a multicenter descriptive study including patients younger than 14 years attending 15 emergency departments and hospitalized with laboratory-confirmed influenza A H1N1 (2009) infection from August to December 2009. Patients who did not meet any of the admission criteria recommended by the Health Spanish Authorities were excluded. A standardized report form was used to collect information on demographics, risk factors, clinical and microbiological data, treatment, and outcome. Potential risk factors associated with intensive care requirement (assisted ventilation and/or inotropic support) were analyzed.</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>Three hundred eight patients were included. The hospitalization rate was 20.5 per 100,000 children younger than 14 years. Median age was 48 months; 21% had underlying medical conditions. The most common diagnosis at admission was presumed bacterial pneumonia (42.5%). Oseltamivir was prescribed on admission to 207 children (67.2%) and antibiotics to 199 (64.6%). Bacterial coinfection was confirmed in 29 patients (9.4%). Fifty-four patients (17.5%) were admitted to an intensive care unit, and 6 (1.9%) died. Logistic regression model revealed that confirmed bacterial coinfection was associated with intensive care requirement (odds ratio, 3.3; 95% confidence interval, 1.1-10.0).</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b></p><p>Respiratory manifestations were the main complication described. Although the majority of patients had a favorable evolution, a remarkable morbidity and mortality were observed. Patients with confirmed bacterial coinfection were at high risk of severe illness.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">23283263</PMID><DateCompleted><Year>2013</Year><Month>06</Month><Day>14</Day></DateCompleted><DateRevised><Year>2013</Year><Month>01</Month><Day>03</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1535-1815</ISSN><JournalIssue CitedMedium="Internet"><Volume>29</Volume><Issue>1</Issue><PubDate><Year>2013</Year><Month>Jan</Month></PubDate></JournalIssue><Title>Pediatric emergency care</Title><ISOAbbreviation>Pediatr Emerg Care</ISOAbbreviation></Journal><ArticleTitle>Hospitalized children with influenza A H1N1 (2009) infection: a Spanish multicenter study.</ArticleTitle><Pagination><MedlinePgn>49-52</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1097/PEC.0b013e31827b528f</ELocationID><Abstract><AbstractText Label="OBJECTIVES" NlmCategory="OBJECTIVE">Even though the majority of cases of influenza A H1N1 (2009) in children are mild, severe complications have been reported. Our objective was to describe the Influenza A H1N1 (2009) complications in pediatric population in Spain.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">This was a multicenter descriptive study including patients younger than 14 years attending 15 emergency departments and hospitalized with laboratory-confirmed influenza A H1N1 (2009) infection from August to December 2009. Patients who did not meet any of the admission criteria recommended by the Health Spanish Authorities were excluded. A standardized report form was used to collect information on demographics, risk factors, clinical and microbiological data, treatment, and outcome. Potential risk factors associated with intensive care requirement (assisted ventilation and/or inotropic support) were analyzed.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Three hundred eight patients were included. The hospitalization rate was 20.5 per 100,000 children younger than 14 years. Median age was 48 months; 21% had underlying medical conditions. The most common diagnosis at admission was presumed bacterial pneumonia (42.5%). Oseltamivir was prescribed on admission to 207 children (67.2%) and antibiotics to 199 (64.6%). Bacterial coinfection was confirmed in 29 patients (9.4%). Fifty-four patients (17.5%) were admitted to an intensive care unit, and 6 (1.9%) died. Logistic regression model revealed that confirmed bacterial coinfection was associated with intensive care requirement (odds ratio, 3.3; 95% confidence interval, 1.1-10.0).</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Respiratory manifestations were the main complication described. Although the majority of patients had a favorable evolution, a remarkable morbidity and mortality were observed. Patients with confirmed bacterial coinfection were at high risk of severe illness.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Hernández-Bou</LastName><ForeName>Susanna</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Pediatric Emergency Department, Hospital Sant Joan de Déu Barcelona, Spain. shernandez@hsjdbcn.org</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Novell</LastName><ForeName>Cristina Borrás</ForeName><Initials>CB</Initials></Author><Author ValidYN="Y"><LastName>Alins</LastName><ForeName>Jara Guardia</ForeName><Initials>JG</Initials></Author><Author ValidYN="Y"><LastName>García-García</LastName><ForeName>Juan José</ForeName><Initials>JJ</Initials></Author><Author ValidYN="Y"><CollectiveName>Infectious Diseases Working Group, Spanish Society of Pediatric Emergencies</CollectiveName></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016448">Multicenter Study</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Pediatr Emerg Care</MedlineTA><NlmUniqueID>8507560</NlmUniqueID><ISSNLinking>0749-5161</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016009" MajorTopicYN="N">Chi-Square Distribution</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002648" MajorTopicYN="N">Child</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002673" MajorTopicYN="Y">Child, Hospitalized</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002675" MajorTopicYN="N">Child, Preschool</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007223" MajorTopicYN="N">Infant</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D053118" MajorTopicYN="Y">Influenza A Virus, H1N1 Subtype</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007251" MajorTopicYN="N">Influenza, Human</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName><QualifierName UI="Q000821" MajorTopicYN="Y">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016015" MajorTopicYN="N">Logistic Models</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012307" MajorTopicYN="N">Risk Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013030" MajorTopicYN="N" Type="Geographic">Spain</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading></MeshHeadingList><InvestigatorList><Investigator ValidYN="Y"><LastName>Sotoca</LastName><ForeName>J V</ForeName><Initials>JV</Initials></Investigator><Investigator ValidYN="Y"><LastName>Maqueda</LastName><ForeName>H</ForeName><Initials>H</Initials></Investigator><Investigator ValidYN="Y"><LastName>Traverı</LastName><ForeName>J</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Iturralde</LastName><ForeName>I</ForeName><Initials>I</Initials></Investigator><Investigator ValidYN="Y"><LastName>Ruano</LastName><ForeName>A</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Suárez</LastName><ForeName>S</ForeName><Initials>S</Initials></Investigator><Investigator ValidYN="Y"><LastName>Astobiza</LastName><ForeName>E</ForeName><Initials>E</Initials></Investigator><Investigator ValidYN="Y"><LastName>Olaciregui</LastName><ForeName>I</ForeName><Initials>I</Initials></Investigator><Investigator ValidYN="Y"><LastName>Herreros</LastName><ForeName>M</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Borras</LastName><ForeName>C</ForeName><Initials>C</Initials></Investigator><Investigator ValidYN="Y"><LastName>García</LastName><ForeName>J J</ForeName><Initials>JJ</Initials></Investigator><Investigator ValidYN="Y"><LastName>Guardia</LastName><ForeName>J</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Hernández-Bou</LastName><ForeName>S</ForeName><Initials>S</Initials></Investigator><Investigator ValidYN="Y"><LastName>Ordóñez</LastName><ForeName>Olga</ForeName><Initials>O</Initials></Investigator><Investigator ValidYN="Y"><LastName>Pociello</LastName><ForeName>N</ForeName><Initials>N</Initials></Investigator><Investigator ValidYN="Y"><LastName>Sánchez</LastName><ForeName>J</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Fleites</LastName><ForeName>L</ForeName><Initials>L</Initials></Investigator><Investigator ValidYN="Y"><LastName>Quintana</LastName><ForeName>S</ForeName><Initials>S</Initials></Investigator><Investigator ValidYN="Y"><LastName>Mambie</LastName><ForeName>M</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Pérez</LastName><ForeName>C</ForeName><Initials>C</Initials></Investigator><Investigator ValidYN="Y"><LastName>Sanchez</LastName><ForeName>R</ForeName><Initials>R</Initials></Investigator></InvestigatorList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2013</Year><Month>1</Month><Day>4</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2013</Year><Month>1</Month><Day>4</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2013</Year><Month>6</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">23283263</ArticleId><ArticleId IdType="doi">10.1097/PEC.0b013e31827b528f</ArticleId><ArticleId IdType="pii">00006565-201301000-00011</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Espagne</li></country></list><tree><noCountry><name sortKey="Alins, Jara Guardia" sort="Alins, Jara Guardia" uniqKey="Alins J" first="Jara Guardia" last="Alins">Jara Guardia Alins</name><name sortKey="Garcia Garcia, Juan Jose" sort="Garcia Garcia, Juan Jose" uniqKey="Garcia Garcia J" first="Juan José" last="García-García">Juan José García-García</name><name sortKey="Novell, Cristina Borras" sort="Novell, Cristina Borras" uniqKey="Novell C" first="Cristina Borrás" last="Novell">Cristina Borrás Novell</name></noCountry><country name="Espagne"><noRegion><name sortKey="Hernandez Bou, Susanna" sort="Hernandez Bou, Susanna" uniqKey="Hernandez Bou S" first="Susanna" last="Hernández-Bou">Susanna Hernández-Bou</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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